Particle therapy tumour outcomes: An updated systematic review

摘要: Particle therapy (PT) offers the potential for reduced normal tissue damage as well escalation of target dose, thereby enhancing therapeutic ratio in radiation therapy. Reflecting building momentum PT use worldwide, construction has recently commenced The Australian Bragg Centre Proton Therapy and Research Adelaide - first centre Australia. This systematic review aims to update clinical evidence base PT, both proton beam carbon ion purpose is inform decision-making referral patients centres Australia they become operational overseas interim. Three major databases were searched by two independent researchers, quality was classified according National Health Medical Council hierarchy. One hundred thirty-six studies included, two-thirds related alone. at very least provides equivalent tumour outcomes compared photon controls with possibility improved control case There suggestion morbidities a range sites, supporting predictions from dosimetric modelling wide international acceptance specific indications based on this. Though promising, this needs be counterbalanced overall low found, 90% level IV (case series) evidence. Prospective comparative trials, supplemented database-derived outcome information, preferably conducted within national networks, are strongly recommended introduced into Australasia.