Exposure to 1800MHz radiofrequency electromagnetic radiation induces oxidative DNA base damage in a mouse spermatocyte-derived cell line

摘要: Abstract Whether exposure to radiofrequency electromagnetic radiation (RF-EMR) emitted from mobile phones can induce DNA damage in male germ cells remains unclear. In this study, we conducted a 24 h intermittent (5 min on and 10 min off) of mouse spermatocyte-derived GC-2 cell line 1800 MHz Global System for Mobile Communication (GSM) signals GSM-Talk mode at specific absorption rates (SAR) 1 W/kg, 2 W/kg or 4 W/kg. Subsequently, through the use formamidopyrimidine glycosylase (FPG) modified comet assay, determined that extent migration was significantly increased SAR Flow cytometry analysis demonstrated levels adduct 8-oxoguanine (8-oxoG) were also These increases concomitant with similar generation reactive oxygen species (ROS); these phenomena mitigated by co-treatment antioxidant α-tocopherol. However, no detectable strand breakage observed alkaline assay. Taking together, findings may imply novel possibility RF-EMR insufficient energy direct induction breaks produce genotoxicity oxidative base cells.