Protein kinase C regulates ionic conductance in hippocampal pyramidal neurons: electrophysiological effects of phorbol esters

摘要: Abstract The vertebrate central nervous system contains very high concentrations of protein kinase C, a calcium- and phospholipid-stimulated phosphorylating enzyme. Phorbol esters, compounds with inflammatory tumor-promoting properties, bind to activate this To clarify the role C in neuronal function, we have localized phorbol ester receptors rat hippocampus by autoradiography examined electrophysiological effects esters on hippocampal pyramidal neurons vitro. blocked calcium-dependent potassium conductance. In addition, late hyperpolarization elicited synaptic stimulation even though other potentials were not affected. The potencies several exerting these actions paralleled their affinities for suggesting that regulates membrane ionic