Translocation (12;22)(p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11

摘要: In myeloid and lymphoid leukemias recurrent chromosomal aberrations can be detected in chromosome region 12p13. We characterized the genes involved t(12;22) (p13;q11) two patients with leukemia one myelodysplastic syndrome (MDS). MN1, a gene on 22q11 was shown to fused TEL, member of family ETS transcription factors The translocation results reciprocal fusion mRNAs, MN1-TEL TEL-MN1, which is likely encode an aberrant factor containing DNA-binding domain TEL. addition TEL PDGF beta receptor t(5;12) chronic myelomonocytic (CMML), our data suggest that involvement this protein leukemogenesis could dual; its isolated protein-protein dimerization domains may crucial for oncogenic activation functionally different proteins.