Clinical significance of E-cadherin as a prognostic marker in thyroid carcinomas.
作者： O Gimm , J Behrends , R von Wasielewski , A Georgii , W Birchmeier
DOI: 10.1210/JCEM.80.7.7608273
关键词: Thyroid 、 Endocrinology 、 Pathology 、 Internal medicine 、 Epithelioma 、 Thyroid carcinoma 、 Immunohistochemistry 、 Immunostaining 、 Carcinoma 、 Anaplasia 、 Medicine 、 Primary tumor
摘要: The aim of this study was to evaluate the expression E-cadherin as a potential marker for prognosis thyroid carcinomas. In normal (n = 8), messenger ribonucleic acid levels uniformly high and seemed be restricted thyrocytes. Steady-state immunostaining were both completely lost in undifferentiated carcinomas 7) variably reduced differentiated 44). follow-up during mean 4.5 +/- 1.4 yr, immunohistochemical compared with initial clinicopathological parameters locoregional recurrence development nodal or distant metastases Immunohistochemical greatly progression primary tumor stage 4 (pT4) tumors. parallel, patients pT4 tumors had higher rate a...
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