The protective effect of different enteral nutrition combined with growth hormone on intestinal mucosal damage of scalded rats
作者： Guanghua Guo , Xiangjun Bai , Chen Cai , Jun Zhang , Xin Li
DOI: 10.1016/J.BURNS.2010.04.003
关键词: Total body surface area 、 Parenteral nutrition 、 Tumor necrosis factor alpha 、 Internal medicine 、 Medicine 、 Venous blood 、 Immunohistochemistry 、 Endocrinology 、 Enteral administration 、 Proliferating cell nuclear antigen 、 Intestinal mucosa 、 Surgery 、 Critical Care and Intensive Care Medicine 、 Emergency medicine 、 General Medicine
摘要: Abstract Objective To investigate the protective effect of standard enteral nutrition (EN) and immunonutrition (EIN) combined with recombinant human growth hormone rhGH on intestinal mucosa damage in scalded rats. Methods Rats subjected to 30% total body surface area (TBSA III°), they were divided randomly into five groups referred as EN, EIN, EN+rhGH, EIN+rhGH control groups. After injury days 1, 4, 7 10, venous blood mucus collected monitor level serum endotoxin, tumor necrosis factor-α (TNF-α) concentration s-IgA. The number IgA plasma cells tissue proliferating cell nuclear antigen (PCNA) detected using method immunohistochemistry. Results PCNA value mucosa, lamina s-IgA EIN EN+rhGH are significantly increased compared those EN group ( P >0.05), while endotoxin TNF-α levels lower than group. Conclusions or has additional treatment reduce rats strengthen protection damage.
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