Effects of enteral nutrition supplemented with glutamine on intestinal mucosal immunity in burned mice.
作者： Jun Fan , Qingyan Meng , Guanghua Guo , Yong Xie , Yiping Xiu
DOI: 10.1016/J.NUT.2008.08.009
关键词:
摘要: Abstract Objective The aim of this study was to investigate the effects enteral nutrition (EN) supplemented with glutamine (GLN) on Peyer's patches and intestinal immunoglobulin A (IgA) response in burned mice. Methods Thirty-four mice were randomly assigned a normal control group ( n = 10), an EN (n 12), GLN (EN + GLN) 12) groups received 20% total body surface area, full-thickness scald burn back. Then fed conventional or for 7 d. There isonitrogenous isocaloric intake groups. On day after injury, entire intestines collected IgA levels, lymphocyte yield, subpopulations, apoptotic ratio analyzed. Results Total numbers levels significantly higher than those P Conclusion results indicated that is superior respect improvement immunity
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sci-hub.se 参考文章(34)
Nelson Jl, Alexander Jw, Multi-trace-element supplementation in enteral formulas for burned guinea pigs. Nutrition. ,vol. 7, pp. 275- 279 ,(1991)
B. Wittig, M. Zeitz, The gut as an organ of immunology International Journal of Colorectal Disease. ,vol. 18, pp. 181- 187 ,(2003) , 10.1007/S00384-002-0444-1
Piyawan Bunpo, Betty Murray, Judy Cundiff, Emma Brizius, Carla J. Aldrich, Tracy G. Anthony, Alanyl-Glutamine Consumption Modifies the Suppressive Effect of l-Asparaginase on Lymphocyte Populations in Mice Journal of Nutrition. ,vol. 138, pp. 338- 343 ,(2008) , 10.1093/JN/138.2.338
Kunitaro Fukuzuka, Carl K. Edwards, Michael Clare-Salzler, Edward M. Copeland, Lyle L. Moldawer, and David W. Mozingo, Glucocorticoid and Fas ligand induced mucosal lymphocyte apoptosis after burn injury. Journal of Trauma-injury Infection and Critical Care. ,vol. 49, pp. 710- 716 ,(2000) , 10.1097/00005373-200010000-00020
Richard S. Hotchkiss, Irene E. Karl, The pathophysiology and treatment of sepsis. The New England Journal of Medicine. ,vol. 348, pp. 138- 150 ,(2003) , 10.1056/NEJMRA021333
Paul E. Wischmeyer, James Lynch, Jennifer Liedel, Rachel Wolfson, Jacob Riehm, Lawrence Gottlieb, Madelyn Kahana, Glutamine administration reduces Gram-negative bacteremia in severely burned patients: a prospective, randomized, double-blind trial versus isonitrogenous control Critical Care Medicine. ,vol. 29, pp. 2075- 2080 ,(2001) , 10.1097/00003246-200111000-00006
Edwin A. Deitch, Role of the gut lymphatic system in multiple organ failure. Current Opinion in Critical Care. ,vol. 7, pp. 92- 98 ,(2001) , 10.1097/00075198-200104000-00007
Folke Hammarqvist, Bo Westman, Carl-Eric Leijonmarck, Kerstin Andersson, Jan Wernerman, Decrease in muscle glutamine, ribosomes, and the nitrogen losses are similar after laparoscopic compared with open cholecystectomy during the immediate postoperative period. Surgery. ,vol. 119, pp. 417- 423 ,(1996) , 10.1016/S0039-6060(96)80142-5
Ying Xin Xu, Alfred Ayala, Barbara Monfils, William G. Cioffi, Irshad H. Chaudry, Mechanism of Intestinal Mucosal Immune Dysfunction Following Trauma–Hemorrhage: Increased Apoptosis Associated with Elevated Fas Expression in Peyer's Patches Journal of Surgical Research. ,vol. 70, pp. 55- 60 ,(1997) , 10.1006/JSRE.1997.5111
Zhongyong Chen, Shiliang Wang, Bin Yu, Ao Li, A comparison study between early enteral nutrition and parenteral nutrition in severe burn patients Burns. ,vol. 33, pp. 708- 712 ,(2007) , 10.1016/J.BURNS.2006.10.380