Somatic Activating PIK3CA Mutations Cause Venous Malformation
作者： Nisha Limaye , Jaakko Kangas , Antonella Mendola , Catherine Godfraind , Matthieu J. Schlögel
DOI: 10.1016/J.AJHG.2015.11.011
关键词: PI3K/AKT/mTOR pathway 、 Cancer research 、 Somatic cell 、 Receptor 、 Phenotype 、 Protein kinase B 、 Receptor tyrosine kinase 、 Endothelial stem cell 、 Molecular biology 、 P110α 、 Biology
摘要: … 2, 5, 8 and that activation of PI3K/AKT is a universal feature of HUVECs expressing mutated TEK.… HUVECs were retrovirally transfected with PIK3CA wild-type or recurrent VM-causative …
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