Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration
作者： Mariona Graupera , Julie Guillermet-Guibert , Lazaros C Foukas , Li-Kun Phng , Robert J Cain
DOI: 10.1038/NATURE06892
关键词: Cell biology 、 Endothelial stem cell 、 Vascular endothelial growth factor B 、 Vascular endothelial growth factor C 、 Vascular endothelial growth inhibitor 、 Vascular endothelial growth factor A 、 Angiogenesis 、 S1PR1 、 Vascular endothelial growth factor 、 Biology
摘要: … In vitro tube formation was also impaired in p110α D933A/… with 50 mg kg -1 body weight BrdU in PBS and killed 2 h later. … -B4 and mouse anti-BrdU as described above. Samples were …
harvard.edu
ed.ac.uk
mdc-berlin.de
nature.com
sci-hub.se 参考文章(31)
Xiang-Dong Ren, Martin Alexander Schwartz, Determination of GTP loading on Rho. Methods in Enzymology. ,vol. 325, pp. 264- 272 ,(2000) , 10.1016/S0076-6879(00)25448-7
Elaine A. Lidington, Ravi M. Rao, Federica M. Marelli-Berg, Parmjit S. Jat, Dorian O. Haskard, Justin C. Mason, Conditional immortalization of growth factor-responsive cardiac endothelial cells from H-2Kb-tsA58 mice American Journal of Physiology-cell Physiology. ,vol. 282, ,(2002) , 10.1152/AJPCELL.2002.282.1.C67
Holger Gerhardt, Christer Betsholtz, How do endothelial cells orientate? Experientia Supplementum. pp. 3- 15 ,(2005) , 10.1007/3-7643-7311-3_1
P. R. Cutillas, A. Khwaja, M. Graupera, W. Pearce, S. Gharbi, M. Waterfield, B. Vanhaesebroeck, Ultrasensitive and absolute quantification of the phosphoinositide 3-kinase/Akt signal transduction pathway by mass spectrometry Proceedings of the National Academy of Sciences of the United States of America. ,vol. 103, pp. 8959- 8964 ,(2006) , 10.1073/PNAS.0602101103
Bart Vanhaesebroeck, Sally J. Leevers, George Panayotou, Michael D. Waterfield, Phosphoinositide 3-kinases: a conserved family of signal transducers. Trends in Biochemical Sciences. ,vol. 22, pp. 267- 272 ,(1997) , 10.1016/S0968-0004(97)01061-X
B. Vanhaesebroeck, M. J. Welham, K. Kotani, R. Stein, P. H. Warne, M. J. Zvelebil, K. Higashi, S. Volinia, J. Downward, M. D. Waterfield, p110δ, a novel phosphoinositide 3-kinase in leukocytes Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 4330- 4335 ,(1997) , 10.1073/PNAS.94.9.4330
Yaz Y Kisanuki, Robert E Hammer, Jun-ichi Miyazaki, S.Clay Williams, James A Richardson, Masashi Yanagisawa, Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo. Developmental Biology. ,vol. 230, pp. 230- 242 ,(2001) , 10.1006/DBIO.2000.0106
Etienne Lelievre, Pierre-Marie Bourbon, Li-Juan Duan, Robert L. Nussbaum, Guo-Hua Fong, Deficiency in the p110α subunit of PI3K results in diminished Tie2 expression and Tie2-/-–like vascular defects in mice Blood. ,vol. 105, pp. 3935- 3938 ,(2005) , 10.1182/BLOOD-2004-10-3955
Hans-Peter Gerber, Vishva Dixit, Napoleone Ferrara, None, Vascular Endothelial Growth Factor Induces Expression of the Antiapoptotic Proteins Bcl-2 and A1 in Vascular Endothelial Cells Journal of Biological Chemistry. ,vol. 273, pp. 13313- 13316 ,(1998) , 10.1074/JBC.273.21.13313
David Chantry, Anne Vojtek, Adam Kashishian, Douglas A. Holtzman, Christi Wood, Patrick W. Gray, Jonathan A. Cooper, Merl F. Hoekstra, p110δ, a Novel Phosphatidylinositol 3-Kinase Catalytic Subunit That Associates with p85 and Is Expressed Predominantly in Leukocytes Journal of Biological Chemistry. ,vol. 272, pp. 19236- 19241 ,(1997) , 10.1074/JBC.272.31.19236