Nodular histiocytic/mesothelial hyperplasia: a potential pitfall.

摘要: We present five cases of nodular histiocytic/mesothelial hyperplasia (two peritoneal, two pulmonary, and one pericardial) with identical microscopic features. All the lesions were biphasic composed cohesive monotonous epithelioid clusters polygonal or oval cells round deeply grooved nuclei in association darker cuboidal cells. Because increased cellularity histologic pattern some degree cytologic atypia, neoplastic processes seriously considered differential diagnoses. The majority marked as histiocytes by immunostain. A few scattered individual small epithelial cell confirmed calretinin stain to be mesothelial patterns current lesions, irrespective location, hyperplasia. Histiocytic proliferations can erroneously confused primary neoplasms such granulosa tumor, eosinophilic granuloma, chronic myelogenous leukemia, carcinoma. purpose this article is describe clinicopathologic features help familiarize pathologists lesion prevent an erroneous diagnosis, particularly when it occurs locations where are not normally present.