Impact of kidney dysfunction on plasma and urinary N-terminal pro-B-type natriuretic peptide in patients with acute heart failure.
作者： Sergio Manzano-Fernández , James Louis Januzzi , Miguel Boronat-García , Patricia Pastor , María Dolores Albaladejo-Otón
DOI: 10.1111/J.1751-7133.2010.00153.X
关键词: Endocrinology 、 Prospective cohort study 、 Natriuretic peptide 、 Internal medicine 、 Heart failure 、 Renal function 、 Urine 、 Gastroenterology 、 Interquartile range 、 Medicine 、 Urinary system 、 Concomitant
摘要: The precise mechanism explaining the increased N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations among patients with concomitant acute heart failure (AHF) and kidney dysfunction is not fully understood. aim of this study was to assess impact on simultaneous measures plasma urinary NT-proBNP in an unselected cohort AHF. One hundred thirty-eight consecutive hospitalized (median age: 74 years; interquartile range: 67-80 54% male) a diagnosis AHF were prospectively studied. Blood urine samples collected hospital arrival determine concentrations. Both declining estimated glomerular filtration rate (eGFR; P<.001 for both). However, after multivariate adjustment, eGFR found be independent predictor (but urinary) concentration (eGFR: β=-0.19; P=.016). Indeed, main determinant its (β=0.42; P<.001), ratio urine/plasma function similar across range examined (P=.368). In dysfunction, circulating may mainly related cardiac secretion decreased renal clearance.
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