High-sensitive cardiac troponin, NT-proBNP, hFABP and copeptin levels in relation to glomerular filtration rates and a medical record of cardiovascular disease.

摘要: Abstract Background Elevation of cardiac markers in patients with renal dysfunction has not been fully assessed reducing the diagnostic usefulness these biomarkers. Objective To examine effects function and a medical record cardiovascular disease on levels Methods Serum samples were collected from 489 referred for GFR measurement using Cr51-EDTA or iohexol plasma clearance (measured GFR). The biomarkers Troponin T (hs-cTnT), I (hsTnI), N-Terminal pro-Brain Natriuretic Peptide (NTproBNP), Copeptin, Human Fatty Acid-Binding Protein (hFABP), as well kidney creatinine cystatin C, measured. Regression was used to analyse relationship between biomarker glomerular filtration rate (GFR) 15 90 mL/min/1.73 m 2 . Results Compared normal function, estimated increases studied at 15 mL/min/1.73 m varied 2-fold 15-fold but very different without most prominent low molecular weight. hs-cTnT correlated more strongly measured increased compared hs-cTnI. For hFABP NTproBNP correctly predicted by local Cystatin C-based eGFR formula creatinine-based (using MDRD CKD-EPI equations). Conclusion extent elevation is highly variable. provides better predictions equations.