Effect of renal function on serum cardiac troponin T--Population and individual effects.
作者： Jason Zhi Yong Chung , Graham Ross Dallas Jones
DOI: 10.1016/J.CLINBIOCHEM.2015.05.004
关键词:
摘要: Abstract Background Elevations of serum cardiac troponin T (cTnT) have been described in patients with end stage chronic kidney disease (CKD) although the mechanism is unknown, whether from increased production or decreased clearance. Less known about cTnT short term changes renal function and lesser degrees impairment. Objectives This study aimed to investigate effect on within individuals characterise distribution according population. Design methods A hospital laboratory database extract was performed for paired creatinine results. compared estimated glomerular filtration rate (eGFR) at population level. In who had undergone repeat testing, were corresponding creatinine. Results At level, 17,113 measurements 10,418 demonstrated rising falling eGFR, no eGFR threshold this effect. Of these, 3108 pairs results obtained testing. The median retesting interval 15 h (interquartile range: 7–25 h). Within individuals, magnitude approximated 33% Conclusions moderate reductions GFR (30-59 mL/min/1.73 m2) corresponded a above 14 ng/L upper reference limit. modest association between further highlights need caution when interpreting elevations setting.
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