A novel strategy for engineering hydrogels with ferromagnetic nanoparticles as crosslinkers of the polymer chains. Potential applications as a targeted drug delivery system
作者： Rolando Barbucci , Daniela Pasqui , Gabriele Giani , Milena De Cagna , Milena Fini
DOI: 10.1039/C1SM05174A
关键词: Polymer 、 Covalent bond 、 Nanotechnology 、 Magnetic nanoparticles 、 Targeted drug delivery 、 Thixotropy 、 Peptide bond 、 Self-healing hydrogels 、 Rheology 、 Materials science
摘要: An efficient strategy is employed for the preparation of magnetic hybrid hydrogels consisting functionalized CoFe2O4 nanoparticles covalently bound to a carboxymethylcellulose (CMC) polymer. The method involves formation an amide bond between carboxylic groups CMC and amine nanoparticles, which work as crosslinking agents polymer chains. were chemically morphologically characterized. rheological properties also investigated with aim verify their behavior under applied mechanical stress. hydrogel turns out be thixotropic. Thanks presence capable responding external field. Preliminary data show possibility loading dye, can considered drug model, squeeze it through syringe drive material by application
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