A comprehensive review of the genetic and biological evidence supports a role for MicroRNA-137 in the etiology of schizophrenia.

摘要: Since it was first associated with schizophrenia (SCZ) in a 2011 genome-wide association study (GWAS), there have been over 100 publications focused on MIR137, the gene encoding microRNA-137. These studies examined everything from its fundamental role development of mice, flies, and fish to intriguing enrichment target network SCZ. Indeed, much excitement surrounding MIR137 is due distinct possibility that could regulate involved SCZ etiology, disease which we now recognize highly polygenic. Here comprehensively review, best our ability, all published genetic biological evidence support or refute for etiology Through careful consideration literature, conclude data gathered date continues strongly involvement neuropsychiatric traits, including risk. There remain, however, more unanswered than answered questions regarding mechanisms linking variation behavior. need answers before can determine whether are opportunities diagnostic therapeutic interventions based MIR137. We number suggestions future research help provide hope greater understanding this devastating disorder.