Dopamine D2 receptor suppresses gastric cancer cell invasion and migration via inhibition of EGFR/AKT/MMP-13 pathway.

作者: Hongli Huang , Kaiming Wu , Jun Ma , Yanlei Du , Chuangyu Cao

DOI: 10.1016/J.INTIMP.2016.07.002

关键词: CancerEndocrinologyCancer researchSignal transductionCarcinogenesisCancer cellEpidermal growth factorProtein kinase BReceptorInternal medicineChemistryPI3K/AKT/mTOR pathway

摘要: … Transwell migration assay The cell migratory ability was tested using transwell migration assay. Briefly, cells at a density of 1 × 10 5 cells/200 μl were placed in the upper chamber, while …

参考文章(28)
Bao-Hui Liu, Li-Quan Wu, Ling-Min Shao, Bao-Wei Ji, Zhen-Tao Guo, Qian-Xue Chen, Xiao-Nan Zhu, Shen-Qi Zhang, Cheng-Jun Li, Ji-An Yang, Qian Yang, LRIG1 enhances the radiosensitivity of radioresistant human glioblastoma U251 cells via attenuation of the EGFR/Akt signaling pathway. International Journal of Clinical and Experimental Pathology. ,vol. 8, pp. 3580- 3590 ,(2015)
TAO YIN, SISI HE, GUOBO SHEN, TINGHONG YE, FUCHUN GUO, YONGSHENG WANG, Dopamine receptor antagonist thioridazine inhibits tumor growth in a murine breast cancer model Molecular Medicine Reports. ,vol. 12, pp. 4103- 4108 ,(2015) , 10.3892/MMR.2015.3967
Hiroko Masuda, Dongwei Zhang, Chandra Bartholomeusz, Hiroyoshi Doihara, Gabriel N. Hortobagyi, Naoto T. Ueno, Role of epidermal growth factor receptor in breast cancer Breast Cancer Research and Treatment. ,vol. 136, pp. 331- 345 ,(2012) , 10.1007/S10549-012-2289-9
Luke H Hoeppner, Ying Wang, Anil Sharma, Naureen Javeed, Virginia P Van Keulen, Enfeng Wang, Ping Yang, Anja C Roden, Tobias Peikert, Julian R Molina, Debabrata Mukhopadhyay, None, Dopamine D2 receptor agonists inhibit lung cancer progression by reducing angiogenesis and tumor infiltrating myeloid derived suppressor cells Molecular Oncology. ,vol. 9, pp. 270- 281 ,(2015) , 10.1016/J.MOLONC.2014.08.008
Siyuan Wang, Zhenzhen Mou, Yuanheng Ma, Jian Li, Jingyun Li, Xiwei Ji, Kehua Wu, Liang Li, Wei Lu, Tianyan Zhou, Dopamine enhances the response of sunitinib in the treatment of drug-resistant breast cancer: Involvement of eradicating cancer stem-like cells. Biochemical Pharmacology. ,vol. 95, pp. 98- 109 ,(2015) , 10.1016/J.BCP.2015.03.013
Lalita Yadav, Naveen Puri, Varun Rastogi, Pranali Satpute, Riyaz Ahmad, Geetpriya Kaur, Matrix metalloproteinases and cancer - roles in threat and therapy. Asian Pacific Journal of Cancer Prevention. ,vol. 15, pp. 1085- 1091 ,(2014) , 10.7314/APJCP.2014.15.3.1085
Federico Gatto, Leo J Hofland, The role of somatostatin and dopamine D2 receptors in endocrine tumors. Endocrine-related Cancer. ,vol. 18, ,(2011) , 10.1530/ERC-10-0334
Sujit Basu, Partha Sarathi Dasgupta, Role of dopamine in malignant tumor growth. Endocrine. ,vol. 12, pp. 237- 241 ,(2000) , 10.1385/ENDO:12:3:237