Dopamine D2 receptor agonists inhibit lung cancer progression by reducing angiogenesis and tumor infiltrating myeloid derived suppressor cells
作者： Luke H Hoeppner , Ying Wang , Anil Sharma , Naureen Javeed , Virginia P Van Keulen
DOI: 10.1016/J.MOLONC.2014.08.008
关键词: Immunology 、 Vascular endothelial growth factor A 、 Angiogenesis 、 Epidermal growth factor receptor 、 Cancer research 、 Lung 、 Lung cancer 、 Agonist 、 Endothelium 、 Biology 、 Myeloid-derived Suppressor Cell
摘要: We sought to determine whether Dopamine D2 Receptor (D2R) agonists inhibit lung tumor progression and identify subpopulations of cancer patients that benefit most from D2R agonist therapy. demonstrate abrogate in syngeneic (LLC1) human xenograft (A549) orthotopic murine models through inhibition angiogenesis reduction infiltrating myeloid derived suppressor cells. Pathological examination tissue revealed a positive correlation between endothelial expression stage. Lung with smoking history exhibited greater levels endothelium. Our results suggest may represent promising individualized therapy for high history.
elsevier.com
moloncol.org 参考文章(51)
J F Zaroslinski, L H Possley, R A Schwartz, R N Morris, F A Carone, R K Browne, The pharmacology and subacute toxicology of dopamine. Journal of the Royal Society of Medicine. ,vol. 70, pp. 2- 6 ,(1977) , 10.1177/00359157770700S202
Sujit Basu, Janice A. Nagy, Soumitro Pal, Eliza Vasile, Isabelle A. Eckelhoefer, V. Susan Bliss, Eleanor J. Manseau, Partha S. Dasgupta, Harold F. Dvorak, Debabrata Mukhopadhyay, The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor. Nature Medicine. ,vol. 7, pp. 569- 574 ,(2001) , 10.1038/87895
Y. Wang, E. F. R. Pereira, A. D. J. Maus, N. S. Ostlie, D. Navaneetham, S. Lei, E. X. Albuquerque, B. M. Conti-Fine, Human Bronchial Epithelial and Endothelial Cells Express α7 Nicotinic Acetylcholine Receptors Molecular Pharmacology. ,vol. 60, pp. 1201- 1209 ,(2001) , 10.1124/MOL.60.6.1201
Sujit Basu, Chandrani Sarkar, Debanjan Chakroborty, Janice Nagy, Rita Basu Mitra, Partha Sarathi Dasgupta, Debabrata Mukhopadhyay, Ablation of Peripheral Dopaminergic Nerves Stimulates Malignant Tumor Growth by Inducing Vascular Permeability Factor/Vascular Endothelial Growth Factor-Mediated Angiogenesis Cancer Research. ,vol. 64, pp. 5551- 5555 ,(2004) , 10.1158/0008-5472.CAN-04-1600
David W Leung, George Cachianes, Wun-Jing Kuang, David V Goeddel, Napoleone Ferrara, None, Vascular endothelial growth factor is a secreted angiogenic mitogen Science. ,vol. 246, pp. 1306- 1309 ,(1989) , 10.1126/SCIENCE.2479986
Jun Chen, Ruoxiang Jiang, Yolanda I. Garces, Aminah Jatoi, Shawn M. Stoddard, Zhifu Sun, Randolph S. Marks, Yunpeng Liu, Ping Yang, Prognostic factors for limited-stage small cell lung cancer: A study of 284 patients Lung Cancer. ,vol. 67, pp. 221- 226 ,(2010) , 10.1016/J.LUNGCAN.2009.04.006
Baisakhi Saha, Amal Chandra Mondal, Sujit Basu, Partha Sarathi Dasgupta, None, Circulating dopamine level, in lung carcinoma patients, inhibits proliferation and cytotoxicity of CD4+ and CD8+ T cells by D1 dopamine receptors: an in vitro analysis. International Immunopharmacology. ,vol. 1, pp. 1363- 1374 ,(2001) , 10.1016/S1567-5769(01)00068-6
Yu Yang, Yanrong Zhang, Santiago Cuevas, Van Anthony Villar, Crisanto Escano, Laureano D. Asico, Peiying Yu, David K. Grandy, Robin A. Felder, Ines Armando, Pedro A. Jose, Paraoxonase 2 decreases renal reactive oxygen species production, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of NADPH oxidase Free Radical Biology and Medicine. ,vol. 53, pp. 437- 446 ,(2012) , 10.1016/J.FREERADBIOMED.2012.05.015
Aidas Nasevicius, Jon Larson, Stephen C. Ekker, Distinct requirements for zebrafish angiogenesis revealed by a VEGF-A morphant. Yeast. ,vol. 17, pp. 294- 301 ,(2000) , 10.1002/1097-0061(200012)17:4<294::AID-YEA54>3.0.CO;2-5
R. K. Jain, Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy Science. ,vol. 307, pp. 58- 62 ,(2005) , 10.1126/SCIENCE.1104819