Role of Pseudomonas aeruginosa Glutathione Biosynthesis in Lung and Soft Tissue Infection

摘要: The opportunistic pathogen Pseudomonas aeruginosa is a leading cause of morbidity and mortality worldwide. To survive in both the environment host, P. must cope with redox stress. In aeruginosa, primary mechanism for protection from stress antioxidant glutathione (GSH). GSH low-molecular-weight thiol-containing tripeptide (l-γ-glutamyl-l-cysteinyl-glycine) that can function as reversible reducing agent. plays an important role physiology known to modulate several cellular social processes are likely during infection. However, biosynthesis mammalian infection not well understood. this study, we created mutant defective examine how loss affects virulence. We found critical normal growth vitro provides against hydrogen peroxide, bleach, ciprofloxacin. also studied four mouse models, including surgical wound, abscess, burn acute pneumonia models. discovered was slightly less virulent model but equally three other This work new complementary data regarding