Pre-diagnostic carbohydrate intake and treatment failure after radical prostatectomy for early-stage prostate cancer

摘要: An association between dietary carbohydrate intake and prostate cancer (PCa) prognosis is biologically plausible, but data are scarce. This prospective cohort study examined the relation pre-diagnostic treatment failure following radical prostatectomy for clinically early-stage PCa. We identified 205 men awaiting assessed their usual of carbohydrates using 110-item Block food frequency questionnaire. also evaluated quality a score based on consumption sugars relative to fiber, fat, protein. Logistic regression analyzed associations with odds failure, defined as detectable rising serum prostate-specific antigen (PSA) or receiving androgen deprivation therapy (ADT) within 2 years. Sucrose was associated higher fiber lower ADT after accounting age, race/ethnicity, body mass index, tumor characteristics (odds ratio [OR] (95% confidence interval [CI]) 5.68 (1.71, 18.9) 3rd vs. 1st sucrose tertile 0.88 (0.81, 0.96) per gram fiber/day, respectively). Increasing (OR CI) 0.78 (0.66, 0.92) unit increase in score, range 0–12). Pre-diagnostic composition influence risk primary Future studies incorporating molecular aspects metabolism could clarify possible underlying mechanisms.