Vasopressin Type-2 Receptor and Aquaporin-2 Water Channel Mutants in Nephrogenic Diabetes Insipidus
作者： PETER M. T. DEEN , NINE V. A. M. KNOERS
DOI: 10.1097/00000441-199811000-00003
关键词: Medicine 、 Vasopressin receptor 、 Aquaporin 2 、 Internal medicine 、 Endocrinology 、 Vasopressin 、 Arginine vasopressin receptor 1B 、 Arginine vasopressin receptor 2 、 Aquaporin 3 、 Nephrogenic diabetes insipidus 、 Diabetes insipidus
摘要: The regulation of water excretion by the kidney is one few physiologic processes that are prominent in everyday life. This process predominantly occurs renal collecting duct cells, where transcellular reabsorption induced after binding pituitary hormone arginine-vasopressin to its vasopressin type-2 receptor and subsequent insertion aquaporin-2 (AQP2) channels apical membrane these cells. Removal triggers endocytosis AQP2 restores water-impermeable state Nephrogenic diabetes insipidus characterized inability concentrate urine response vasopressin; channel have both been shown be involved this disease. article focuses on mutations V2 identified nephrogenic patients, effects transport function proteins upon expression cell systems.
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