Minor role of hepatitis B virus in the causation of chronic liver disease in Somalia indicated by a case-control study.

摘要: Chronic liver disease (CLD) is frequent in Somalia. In a case-control study, 116 in-patients with CLD were compared the same number of age and sex matched controls. Demographic variables, use drugs, symptoms signs, serological markers for hepatitis B virus (HBV) serum alpha-foetoprotein (AFP) assessed. Hepatitis surface antigen (HBsAg) was found 44 cases which 17 had antibodies to D (anti-HD) 7 e (HBeAg). Twenty-three controls HBsAg-positive, whom 3 anti-HD one HBeAg. Increased relative risks (95% confidence intervals parentheses) 2.5 (1.3-4.5) HBsAg, 6.5 (1.7-21.5) anti-HD, 7.4 (0.9-66.5) Despite association between presence HBV CLD, 62% no indicating current infection. This reflected low risk attributable chronic infection (22.6%), lower than that patients other African populations high HBsAg carrier rate. The prevalence did not differ AFP greater 100 ng/ml those less ng/ml. former characterized by male predominance, shorter duration symptoms, larger mean size, indicative malignancy. HBsAg-positive significantly (by 7.7 years) HBsAg-negative Among ng/ml, 48 HBsAg-negative. These differed from 68 more females (35% against 16%), originated an agricultural area (56% 30%), regular consumers drugs (48% 28%). conclusion, factors as yet undefined play considerable role causation possibility determining C (HCV) awaits development specific assays anti-HCV antibodies.