Evidence for a parathyroid hormone-dependent influence of calcium on the glomerular ultrafiltration coefficient.

摘要: Experiments were performed on 36 plasma-expanded Munich-Wistar rats to examine the effects of acute hypercalcemia determinants glomerular ultrafiltration. Elevation total plasma calcium concentration an average value 13.2 +/- 0.5 mg/dl, by infusion chloride into nonthyroparathyroidectomized (non-TPTX) rats, resulted in significant declines single nephron and whole kidney filtration rate. These due primarily a fall capillary ultrafiltration coefficient (Kf), mean approximately 60% below that determined pre-infusion period. changes not seen separate group sham-treated non-TPTX rats. It is interest these largely abolished underwent TPTX before hypercalcemia. Infusion submaximally phosphaturic dose parathyroid hormone, together with chloride, second however, had effect reproducing striking rate Kf noted given alone. findings suggest decline associated reduction Kf, latter dependent upon presence hormone.