Modulation Of Renin Secretion By Renal Cortical Interstitial Calcium
作者： Douglas K. Atchison
DOI:
关键词: Parathyroid hormone 、 Endocrinology 、 Calcium-sensing receptor 、 Calcium 、 Afferent arterioles 、 Renin–angiotensin system 、 Kidney 、 Calcium metabolism 、 Plasma renin activity 、 Internal medicine 、 Chemistry
摘要: MODULATION OF RENIN SECRETION BY RENAL CORTICAL INTERSTITIAL CALCIUM by DOUGLAS K. ATCHISON May 2012 Advisor: Dr. William Beierwaltes Major: Physiology Degree: Doctor of Philosophy Renin is secreted from the juxtaglomerular (JG) cells afferent arteriole kidney, and rate-limiting enzyme renin-angiotensin system. quantified in vivo as plasma renin activity (PRA). Acutely elevating calcium decreases PRA, but mechanisms which this occurs unknown. The overall goal our study was to determine how elevated PRA. calcium-sensing receptor (CaSR) a ubiquitously expressed that translates changes into intracellular signaling. JG are basolaterally bordered renal cortical interstitium, parathyroid hormone (PTH) positively regulates concentration interstitium. Thus, we hypothesized hypercalcemia inhibits PRA via PTH-mediated increases interstitial Ca act on CaSR triggering Ca-mediated inhibition secretion. We demonstrated vivo. Additionally, acutely stimulating with pharmacological agonists decrease basal stimulated anesthetized rats parathyroid-intact parathyroidectomized (PTX) rats. acute decreased blocked antagonists PTX.
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