Parallel but independent effects of pentobarbital and scopolamine on hippocampus-related behavior

摘要: In Wistar-derived rats subanesthetic doses of pentobarbital were found to abolish spontaneous alternation, a form exploratory behavior selectively sensitive hippocampal damage and (until now) anticholinergic drugs. A dose 15 mg/kg completely abolished the behavior, as did scopolamine 0.3 mg/kg. Dose-response curves for two drugs could be closely superimposed on assumption that potency ratio was about 45:1. Combined injections drugs, with each employed at barely subthreshold dosage, not reliably reduce alternation rate, although superthreshold combination alternation. All effects predicted basis electrophysiological-pharmacological studies showing drug affect electrical activity in different way. Pentobarbital, scopolamine, massive lesions have now been same behavioral least five highly diagnostic responses.