Effects of cholinergic and monoaminergic antagonists and tranquilizers upon spatial memory in rats
作者： Y HIRAGA , T IWASAKI
DOI: 10.1016/0091-3057(84)90243-0
关键词:
摘要: To explore the pharmacological mechanisms of spatial memory, performance on radial arm maze was tested in rats under following drugs, using a within-subject design; scopolamine (0.25 and 0.5 mg/kg), methylscopolamine (0.5 1 phentolamine (5 10 propranolol (10 20 chlorpromazine (1 2 chlordiazepoxide mg/kg). The number correct choices significantly decreased by scopolamine, while other including methylscopolamine, showed no effects choices. Almost all drugs affected running time. These findings indicate that brain cholinergic system is involved memory.
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