Functional and Evolutionary Insights into Human Brain Development through Global Transcriptome Analysis
作者： Matthew B. Johnson , Yuka Imamura Kawasawa , Christopher E. Mason , Željka Krsnik , Giovanni Coppola
DOI: 10.1016/J.NEURON.2009.03.027
关键词: Human brain 、 Computational biology 、 Alternative splicing 、 Gene expression 、 Genetics 、 Gene 、 Transcriptome 、 Gene expression profiling 、 Prefrontal cortex 、 Biology 、 Regulation of gene expression
摘要: Our understanding of the evolution, formation, and pathological disruption human brain circuits is impeded by a lack comprehensive data on developing transcriptome. A whole-genome, exon-level expression analysis 13 regions from left right sides mid-fetal revealed that 76% genes are expressed, 44% these differentially regulated. These reveal large number specific gene alternative splicing patterns, as well coexpression networks, associated with distinct neurodevelopmental processes. Of particular relevance to cognitive specializations, we have characterized transcriptional landscapes prefrontal cortex perisylvian speech language areas, which exhibit population-level global symmetry. We show expressed more frequently human-specific evolution putative cis-regulatory elements. provide wealth biological insights into complex molecular underpinnings development evolution.
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