CD70 represents the human ligand for CD27

作者： Rogier Q. Hintzen , Susanne M. A. Lens , Gerrit Koopman , Steven T. Pals , Hergen Spits

关键词: Antigen 、 Stromal cell 、 Germinal center 、 CD40 、 Tumor necrosis factor alpha 、 Molecular biology 、 Biology 、 Lymphotoxin beta 、 Cell culture 、 Cell surface receptor 、 Internal medicine 、 Endocrinology

摘要: The recently identified CD27 ligand (L) is a type II transmembrane molecule with significant structural homology to tumor necrosis factor (TNF)-alpha, TNF-beta, lymphotoxin beta, CD40L, and CD30L. Using CD27L specific mAb we examined the tissue distribution of molecule, found its expression be restricted B cells in occasional germinal centers, stromal thymic medulla, scattered T tonsils, skin gut. As limited closely resembled reported activation antigen CD70, tested whether CD70 represents human CD27L. were react CD27L-expressing transfected mouse fibroblasts. Moreover number could specifically interfere cellular binding mAb. Thus, identical