Autophagy is required for CSF-1–induced macrophagic differentiation and acquisition of phagocytic functions
作者： Arnaud Jacquel , Sandrine Obba , Laurent Boyer , Maeva Dufies , Guillaume Robert
DOI: 10.1182/BLOOD-2011-11-392167
关键词: Autophagy 、 Autophagy-Related Protein-1 Homolog 、 Biology 、 Cell biology 、 Lysosome 、 ULK1 、 Autophagy-Related Protein 7 、 Monocyte differentiation 、 Cellular homeostasis 、 Macrophage
摘要: Autophagy is the process by which superfluous or damaged macromolecules organelles are degraded lysosome. Pharmacologic and genetic evidence indicates that autophagy plays pleiotropic functions in cellular homeostasis, development, survival, differentiation. The differentiation of human blood monocytes into macrophages a caspase-dependent when triggered ex vivo colony stimulating factor-1. We show here, using pharmacologic inhibitors, siRNA approaches, Atg7-/- mice, initiated ULK1 required for proper factor-1-driven murine monocytes. also unravel role macrophage acquisition phagocytic functions. Collectively, these findings highlight an unexpected essential during monocyte
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bloodjournal.org参考文章(20)
Bin-Zhi Qian, Jiufeng Li, Hui Zhang, Takanori Kitamura, Jinghang Zhang, Liam R. Campion, Elizabeth A. Kaiser, Linda A. Snyder, Jeffrey W. Pollard, CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis Nature. ,vol. 475, pp. 222- 225 ,(2011) , 10.1038/NATURE10138
Linda M. Stephenson, Brian C. Miller, Aylwin Ng, Jason Eisenberg, Zijiang Zhao, Ken Cadwell, Daniel B. Graham, Noboru N. Mizushima, Ramnik Xavier, Herbert W. Virgin, Wojciech Swat, Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes. Autophagy. ,vol. 5, pp. 625- 635 ,(2009) , 10.4161/AUTO.5.5.8133
Saul J. Priceman, James L. Sung, Zory Shaposhnik, Jeremy B. Burton, Antoni X. Torres-Collado, Diana L. Moughon, Mai Johnson, Aldons J. Lusis, Donald A. Cohen, M. Luisa Iruela-Arispe, Lily Wu, Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy Blood. ,vol. 115, pp. 1461- 1471 ,(2010) , 10.1182/BLOOD-2009-08-237412
Zhifen Yang, Daniel J. Klionsky, Eaten alive: a history of macroautophagy. Nature Cell Biology. ,vol. 12, pp. 814- 822 ,(2010) , 10.1038/NCB0910-814
Rajat Singh, Youqing Xiang, Yongjun Wang, Kiran Baikati, Ana Maria Cuervo, Yen K Luu, Yan Tang, Jeffrey E Pessin, Gary J Schwartz, Mark J Czaja, None, Autophagy regulates adipose mass and differentiation in mice Journal of Clinical Investigation. ,vol. 119, pp. 3329- 3339 ,(2009) , 10.1172/JCI39228
Yan Zhang, Michael J. Morgan, Kun Chen, Swati Choksi, Zheng-gang Liu, Induction of autophagy is essential for monocyte-macrophage differentiation Blood. ,vol. 119, pp. 2895- 2905 ,(2012) , 10.1182/BLOOD-2011-08-372383
David C Rubinsztein, Guillermo Mariño, Guido Kroemer, None, Autophagy and Aging Cell. ,vol. 146, pp. 682- 695 ,(2011) , 10.1016/J.CELL.2011.07.030
Ellen Wirawan, Tom Vanden Berghe, Saskia Lippens, Patrizia Agostinis, Peter Vandenabeele, Autophagy: for better or for worse Cell Research. ,vol. 22, pp. 43- 61 ,(2012) , 10.1038/CR.2011.152
Christian Steidl, Tang Lee, Sohrab P Shah, Pedro Farinha, Guangming Han, Tarun Nayar, Allen Delaney, Steven J Jones, Javeed Iqbal, Dennis D Weisenburger, Martin A Bast, Andreas Rosenwald, Hans-Konrad Muller-Hermelink, Lisa M Rimsza, Elias Campo, Jan Delabie, Rita M Braziel, James R Cook, Ray R Tubbs, Elaine S Jaffe, Georg Lenz, Joseph M Connors, Louis M Staudt, Wing C Chan, Randy D Gascoyne, None, Tumor-Associated Macrophages and Survival in Classic Hodgkin's Lymphoma The New England Journal of Medicine. ,vol. 362, pp. 875- 885 ,(2010) , 10.1056/NEJMOA0905680
M Mortensen, DJP Ferguson, M Edelmann, B Kessler, KJ Morten, M Komatsu, AK Simon, None, Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 832- 837 ,(2010) , 10.1073/PNAS.0913170107