Dynamic capillary coatings for electroosmotic flow control in capillary electrophoresis

摘要: Abstract Control of the electroosmotic flow (EOF) is critical for achieving optimal separations by capillary electrophoresis. For instance, manipulation EOF can yield either high resolution or rapid analyses. Dynamic coatings are a simple and cost-effective approach to altering EOF. The normal be slowed using buffer additives such as Mg 2+ hexamethonium which ion exchange onto surface silanols lower effective wall charge. Alternatively, cationic polyelectrolytes surfactants used establish coating on wall, results in reversed Practical considerations pH stability reproducibility obtainable with an modifier will discussed.