Overexpression of Transforming Growth Factor-β1 in Scirrhous Carcinoma of the Stomach Correlates with Decreased Survival
作者： Shoichi Kinugasa , Shun’ichi Abe , Mitsuo Tachibana , Yoshitaka Hishikawa , Hiroshi Yoshimura
DOI: 10.1159/000011916
关键词: Stomach 、 Immunohistochemistry 、 Log-rank test 、 Transforming growth factor 、 Pathology 、 Internal medicine 、 Survival analysis 、 Adenocarcinoma 、 Gastroenterology 、 Survival rate 、 Proliferating cell nuclear antigen 、 Biology
摘要: A retrospective study of 50 patients with scirrhous carcinoma the stomach who had undergone surgery was performed to elucidate whether immunohistochemical overexpression transforming growth factor-beta1 (TGF-beta1) could predict patients' survival. To evaluate proliferative activity tumor, proliferating cell nuclear antigen (PCNA) index used. Expression TGF-beta1 low in 27 and high 23. Clinicopathological characteristics were not significantly different between two groups expression. Tumors higher expression PCNA indices (p = 0.0467, unpaired Student's t test). The 5-year survival rate 40.4% for group 28.7% 0.0388, log rank By multivariate analysis, pT, residual independent prognostic factors. These results suggest that is one useful predictors estimating particularly T3 T4 stages.
sci-hub.se 参考文章(27)
Kiyomi Taniyama, Hiromichi Sumiyoshi, Eiichi Tahara, Wataru Yasui, Shinji Nagae, Jotaro Hata, Tomonori Hayashi, Shunji Sakamoto, Human epidermal growth factor in gastric carcinoma as a biologic marker of high malignancy Japanese Journal of Cancer Research. ,vol. 77, pp. 145- 152 ,(1986) , 10.20772/CANCERSCI1985.77.2_145
Seiki Matsuno, Hiroshi Nagura, Takayuki Mizoi, Haruo Ohtani, Masaaki Miyazawa, Kohei Miyazono, Immunoelectron Microscopic Localization of Transforming Growth Factor β1 and Latent Transforming Growth Factor β1 Binding Protein in Human Gastrointestinal Carcinomas: Qualitative Difference between Cancer Cells and Stromal Cells Cancer Research. ,vol. 53, pp. 183- 190 ,(1993)
Yoshitaka Nagai, Teiichi Motoyama, Toshimitsu Suzuki, Hidenobu Watanabe, Kooko Sakakibara, Biosynthesis of an Interstitial Type of Collagen by Cloned Human Gastric Carcinoma Cells Cancer Research. ,vol. 42, pp. 2019- 2027 ,(1982)
Oliver Howard Beahrs, Max H. Myers, Manual for Staging of Cancer ,(1992)
Leslie I. Gold, Bradley A. Arrick, Stefan M. Gorsch, Vincent A. Memoli, Thérèse A. Stukel, Immunohistochemical staining for transforming growth factor beta 1 associates with disease progression in human breast cancer. Cancer Research. ,vol. 52, pp. 6949- 6952 ,(1992)
D.P. Lane, N.H. Waseem, Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA). Structural conservation and the detection of a nucleolar form. Journal of Cell Science. ,vol. 96, pp. 121- 129 ,(1990) , 10.1242/JCS.96.1.121
T. Inoue, T. Ishida, M. Takenoyama, K. Sugio, K. Sugimachi, The relationship between the immunodetection of transforming growth factor-β in lung adenocarcinoma and longer survival rates** Surgical Oncology-oxford. ,vol. 4, pp. 51- 57 ,(1995) , 10.1016/S0960-7404(10)80031-3
Rik Derynck, Julie A. Jarrett, Ellson Y. Chen, Dennis H. Eaton, John R. Bell, Richard K. Assoian, Anita B. Roberts, Michael B. Sporn, David V. Goeddel, Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells. Nature. ,vol. 316, pp. 701- 705 ,(1985) , 10.1038/316701A0
Yasuhisa Naito, Isamu Kino, Kentaro Horiuchi, Daisaburo Fujimoto, Promotion of collagen production by human fibroblasts with gastric cancer cellsin vitro Virchows Archiv B Cell Pathology Including Molecular Pathology. ,vol. 46, pp. 145- 154 ,(1984) , 10.1007/BF02890304
Al Candel, Linda Green, Melanie Castelli, Kurian Abraham, Gerard Aranga, Paolo Gattuso, Flow cytometry as a prognostic predictor in gastric linitis plastica. Journal of Surgical Oncology. ,vol. 56, pp. 233- 235 ,(1994) , 10.1002/JSO.2930560406