Cholesterol feeding increases plasma and aortic tissue cholesterol oxide levels in parallel: further evidence for the role of cholesterol oxidation in atherosclerosis.
作者： Howard N. Hodis , Donald W. Crawford , Alex Sevanian
DOI: 10.1016/0021-9150(91)90051-4
关键词: Cholesterol oxide 、 Chemistry 、 Endocrinology 、 Lagomorpha 、 Aorta 、 Internal medicine 、 Cholesterol feeding 、 Aortic tissue 、 Cholesterol 、 Pathophysiology 、 Oxysterol
摘要: Abstract To determine the relationship between plasma and arterial wall oxysterols, aortic tissue from 7 New Zealand White rabbits fed a high cholesterol (1%) diet for 6 weeks was compared to normocholesterolemic standard rabbit chow. Cholesterol oxide fractions were isolated analyzed by gas chromatography. Normocholesterolemic contained low levels of cholest-5-ene-3β,7α-diol, cholesta-3,5-dien-7-one, 5,6α-epoxy-5α-cholestan-3α-ol, cholest-5-ene-3β,7β-diol, 5α-cholestane-3β,5,6/gb-triol while hypercholesterolemic atherosclerotic aorta significantly higher (P
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