Prognostic factors of 305 nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy.

摘要: BACKGROUND AND OBJECTIVE Radiotherapy is effective in treating nasopharyngeal carcinoma (NPC). This study evaluated the treatment efficacy, toxicity, and prognostic factors of intensity-modulated radiotherapy (IMRT) NPC. METHODS Between September 2003 2006, 305 patients with NPC were treated IMRT Fujian Provincial Cancer Hospital. was delivered as follows: gross tumor volume (GTV) received 66.0-69.8 Gy 30-33 fractions, high-risk clinical target (CTV-1) 60.0-66.65 Gy, low-risk (CTV-2) cervical lymph node regions (CTV-N) 54.0-55.8 Gy. Patients stages III or IV disease also cisplatin-based chemotherapy. All assessed for local-regional control, survival, toxicity. RESULTS With a median follow-up 35 months (range, 5-61 months), there 16, 8, 39 who had developed local, regional, distant recurrence, respectively. The 3-year rates local regional metastasis-free disease-free overall survival 94.3%, 97.7%, 86.1%, 80.3%, 89.1%, Multivariate analyses revealed that T-classification no predictive value control whereas N-classification significant factor (P < 0.001), = 0.003). For III-IV disease, concurrent adjuvant chemotherapy did not influence prognosis. most severe acute toxicities included Grade mucositis 14 (4.6%), skin desquamation 90 (29.5%), Grades leucocytopenia 20 (6.5%). There 7% II xerostomia after 2 years IMRT, 3 4 detected. CONCLUSIONS provided favorable locoregional NPC, even those locally advanced disease. late acceptable. main Further needed on