Long‑term results of concurrent chemoradiotherapy for T3/T4 locally advanced nasopharyngeal carcinoma

摘要: Nasopharyngeal carcinoma (NPC) is one of the most commonly diagnosed head and neck malignancies. This study investigated outcome locally advanced NPC patients on concurrent intensity-modulated radiation therapy (IMRT) chemotherapy with docetaxel, cisplatin 5-fluorouracil (TPF). A total 226 received IMRT, a dose 65–70 Gy chemotherapy, 2 cycles TPF administered during radiotherapy, between March, 2005 2007. An additional to 4 were every 21 days following radiotherapy. With median follow-up time 35 months (range, 7–60), 5-year overall survival (OS) rate was 81.4%, 93.6 75.0% for T3 T4 lesions, respectively, (P=0.001). The progression-free (PFS) 50.4%, 66.7 46.9% respectively (P<0.001). T-classification significant prognostic factor PFS OS. subgroup analysis revealed that pterygopalatine fossa invasion associated significantly lower (P=0.001) OS (P=0.002), foramen rotundum (P<0.001) (P=0.004), ovale (P=0.013) (P=0.024) lacerum cavernous sinus (P<0.001 P<0.001, respectively). Concurrent chemoradiotherapy an advocated regimen NPC, since it exhibits satisfactory rates. Our results suggest estimation invasive range may identify higher risk locoregional failure who be better candidates this treatment strategy.