Dopa decarboxylase (Ddc) affects variation in Drosophila longevity.

摘要: Mutational analyses in model organisms have shown that genes affecting metabolism and stress resistance regulate life span, but the responsible for variation longevity natural populations are largely unidentified. Previously, we mapped quantitative trait loci (QTLs) between two Drosophila melanogaster strains. Here, show QTL 36E;38B cytogenetic interval on chromosome 2 contains multiple closely linked QTLs, including Dopa decarboxylase (Ddc) locus. Complementation tests to mutations Ddc is a positional candidate gene span these Linkage disequilibrium (LD) mapping sample of 173 alleles from single population shows three common molecular polymorphisms account 15.5% genetic contribution variance 2. The strong LD, effects haplotypes suggest maintained by balancing selection. DDC catalyzes final step synthesis neurotransmitters, dopamine serotonin. Thus, data implicate bioamines as factor contributing individual span.