Adaptive protein evolution at the Adh locus in Drosophila
作者： John H. McDonald , Martin Kreitman
DOI: 10.1038/351652A0
关键词: Drosophila yakuba 、 Nearly neutral theory of molecular evolution 、 Locus (genetics) 、 Molecular evolution 、 McDonald–Kreitman test 、 Neutral mutation 、 Evolutionary biology 、 Biology 、 Genetics 、 Drosophila melanogaster 、 Fixation (population genetics)
摘要: Proteins often differ in amino-acid sequence across species. This difference has evolved by the accumulation of neutral mutations random drift, fixation adaptive selection, or a mixture two. Here we propose simple statistical test protein evolution hypothesis based on comparison number replacement substitutions to synonymous coding region locus. If observed are neutral, ratio fixed differences between species should be same as polymorphisms within DNA data Adh locus (encoding alcohol dehydrogenase, EC 1.1.1.1) three Drosophila melanogaster subgroup do not fit this expectation; instead, there more than expected. We suggest that these excess result from selectively advantageous mutations.
nature.com
harvard.edu
eurekamag.com 参考文章(14)
C. Collet, Recent origin for a thermostable alcohol dehydrogenase allele ofDrosophila melanogaster Journal of Molecular Evolution. ,vol. 27, pp. 142- 146 ,(1988) , 10.1007/BF02138374
Randall K Saiki, Teodorica L Bugawan, Glenn T Horn, Kary B Mullis, Henry A Erlich, None, Analysis of enzymatically amplified β-globin and HLA-DQα DNA with allele-specific oligonucleotide probes Nature. ,vol. 324, pp. 163- 166 ,(1986) , 10.1038/324163A0
J. A. Sved, Possible Rates of Gene Substitution in Evolution The American Naturalist. ,vol. 102, pp. 283- 293 ,(1968) , 10.1086/282542
Russell G. Higuchi, Howard Ochman, Production of single-stranded DNA templates by exonuclease digestion following the polymerase chain reaction Nucleic Acids Research. ,vol. 17, pp. 5865- 5865 ,(1989) , 10.1093/NAR/17.14.5865
Robert J Zagursky, Kirk Baumeister, Nancy Lomax, Michael L Berman, Rapid and easy sequencing of large linear double-stranded DNA and supercoiled plasmid DNA Gene Analysis Techniques. ,vol. 2, pp. 89- 94 ,(1985) , 10.1016/0735-0651(85)90011-1
Paul M. Sharp, Wen-Hsiung Li, On the rate of DNA sequence evolution in Drosophila Journal of Molecular Evolution. ,vol. 28, pp. 398- 402 ,(1989) , 10.1007/BF02603075
J. B. S. Haldane, The cost of natural selection Journal of Genetics. ,vol. 55, pp. 511- 524 ,(1957) , 10.1007/BF02984069
Mark Bodmer, Michael Ashburner, Conservation and change in the DNA sequences coding for alcohol dehydrogenase in sibling species of Drosophila Nature. ,vol. 309, pp. 425- 430 ,(1984) , 10.1038/309425A0
Organization and evolution of the alcohol dehydrogenase gene in Drosophila. Molecular Biology and Evolution. ,vol. 5, pp. 154- 166 ,(1988) , 10.1093/OXFORDJOURNALS.MOLBEV.A040487
J Maynard Smith, None, “Haldane's Dilemma” and the Rate of Evolution Nature. ,vol. 219, pp. 1114- 1116 ,(1968) , 10.1038/2191114A0