Tribbles in disease: Signaling pathways important for cellular function and neoplastic transformation
作者： Takashi Yokoyama , Takuro Nakamura
DOI: 10.1111/J.1349-7006.2011.01914.X
关键词: Signal transduction 、 Transcription factor 、 Neoplastic transformation 、 Cell biology 、 ATF4 、 Kinase 、 MAPK/ERK pathway 、 Genetics 、 Protein kinase A 、 Biology 、 Activating Transcription Factor 4
摘要: The tribbles family of genes encodes pseudokinase proteins that are highly conserved in evolution. Instead direct phosphorylation target proteins, act as adaptors signaling pathways for important cellular processes. These include mitogen-activated protein kinase (MAPKK), CCAAT/enhancer-binding (C/EBP), activating transcription factor 4 (ATF4) and C/EBP-homologous (CHOP). Trib1 Trib2 have been identified myeloid oncogenes, both may be involved human leukemia. Tribbles also a series non-neoplastic disorders including metabolic neurological diseases. RAS/mitogen-activated (MAPK) pathway molecules (in particular MAPK/ERK 1 (MEK1) C/EBP factors) tribbles-binding leukemogenesis, the role linker between MAPK degradation is proposed. Although molecular function still under investigation, research on processes, homeostasis organisms diseases will provide valuable information therapy cancer well disorders. (Cancer Sci 2011; 102: 1115–1122)
sci-hub.se 参考文章(75)
K. Du, TRB3: A tribbles Homolog That Inhibits Akt/PKB Activation by Insulin in Liver Science. ,vol. 300, pp. 1574- 1577 ,(2003) , 10.1126/SCIENCE.1079817
Claus Nerlov, C/EBPalpha mutations in acute myeloid leukaemias. Nature Reviews Cancer. ,vol. 4, pp. 394- 400 ,(2004) , 10.1038/NRC1363
Ling Qi, Jose E Heredia, Judith Y Altarejos, Robert Screaton, Naomi Goebel, Sherry Niessen, Ian X MacLeod, Chong Wee Liew, Rohit N Kulkarni, James Bain, Christopher Newgard, Michael Nelson, Ronald M Evans, John Yates, Marc Montminy, TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science. ,vol. 312, pp. 1763- 1766 ,(2006) , 10.1126/SCIENCE.1123374
Seung-Hoi Koo, Hiroaki Satoh, Stephan Herzig, Chih-Hao Lee, Susan Hedrick, Rohit Kulkarni, Ronald M Evans, Jerrold Olefsky, Marc Montminy, PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3 Nature Medicine. ,vol. 10, pp. 530- 534 ,(2004) , 10.1038/NM1044
Steven K. Hanks, Tony Hunter, Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. The FASEB Journal. ,vol. 9, pp. 576- 596 ,(1995) , 10.1096/FASEBJ.9.8.7768349
Masamichi Imajo, Eisuke Nishida, Human Tribbles homolog 1 functions as a negative regulator of retinoic acid receptor Genes to Cells. ,vol. 15, pp. 1089- 1097 ,(2010) , 10.1111/J.1365-2443.2010.01445.X
Alex J Bowers, Sheila Scully, John F Boylan, SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia Oncogene. ,vol. 22, pp. 2823- 2835 ,(2003) , 10.1038/SJ.ONC.1206367
Helit Nabel-Rosen, Hila Toledano-Katchalski, Gloria Volohonsky, Talila Volk, Cell Divisions in the Drosophila Embryonic Mesoderm Are Repressed via Posttranscriptional Regulation of string/cdc25 by HOW Current Biology. ,vol. 15, pp. 295- 302 ,(2005) , 10.1016/J.CUB.2005.01.045
Vesna Cvetkovic-Lopes, Laurence Bayer, Stéphane Dorsaz, Stéphanie Maret, Sylvain Pradervand, Yves Dauvilliers, Michel Lecendreux, Gert-Jan Lammers, Claire E.H.M. Donjacour, Renaud A. Du Pasquier, Corinne Pfister, Brice Petit, Hyun Hor, Michel Mühlethaler, Mehdi Tafti, Elevated Tribbles homolog 2–specific antibody levels in narcolepsy patients Journal of Clinical Investigation. ,vol. 120, pp. 713- 719 ,(2010) , 10.1172/JCI41366
S. Prudente, M. L. Hribal, E. Flex, F. Turchi, E. Morini, S. De Cosmo, S. Bacci, V. Tassi, M. Cardellini, R. Lauro, G. Sesti, B. Dallapiccola, V. Trischitta, The Functional Q84R Polymorphism of Mammalian Tribbles Homolog TRB3 Is Associated With Insulin Resistance and Related Cardiovascular Risk in Caucasians From Italy Diabetes. ,vol. 54, pp. 2807- 2811 ,(2005) , 10.2337/DIABETES.54.9.2807