Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification.

摘要: The eukaryotic protein kinases make up a large superfamily of homologous proteins. They are related by virtue their kinase domains (also known as catalytic domains), which consist approximately 250-300 amino acid residues. that define this group enzymes contain 12 conserved subdomains fold into common core structure, revealed the 3-dimensional structures several protein-serine kinases. There two main subdivisions within superfamily: protein-serine/threonine and protein-tyrosine A classification scheme can be founded on domain phylogeny, reveals families have substrate specificities modes regulation.