Characteristics and evaluation of an injectable clarithromycin lipid-based complex in vitro and in vivo.
作者： Yan Ma , HaiGang Li , ShiXia Guan , None
DOI: 10.3109/10717544.2013.834415
关键词: Colloid 、 Ionic strength 、 Buffer solution 、 Ultrafiltration 、 Sodium 、 Chromatography 、 Phospholipid 、 Particle size 、 Chemistry 、 Tris
摘要: AbstractThe purpose of this paper is to prepare a less-irritating and lipid-based clarithromycin complex (LCC) by the route intravenous administration qualified with high drug-loading fine particle size. The LCC was prepared injection organic solvent phase (containing clarithromycin, sodium cholesterol sulfate phospholipid at molar ratio 1:1:1.5) into Tris buffer solution (0.05 M, pH 7.2) 40 °C, then concentrated ultrafiltration remove solvent. technique lyophilization applied obtain lyophilized products. Evaluation injectable performed sizes analysis, transmission electron microscope, entrapment efficiency, stability irritation tests. possessed log-normal size distribution an average 75.4 nm. drug efficiency above 97.0%, which influenced amount phospholipid, value media ionic strength aqueous suspension. results sta...
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