Formulation and evaluation of less-painful clarithromycin lipid microspheres

摘要: Lipid microspheres (LMs) have recently been use as drug carriers for intravenous due to its low toxicity, good physiological tolerance and the reduction of related side-effect. In this study, clarithromycin was incorporated in LMs, an attempt reduce pain caused by use. The composition loaded LMs 0.5%, oil phase 10%, soybean phospholipid 2%, egg lecithin Sodium oleate 0.1%. Clarithromycin prepared high pressure homogenization method at 80 MPa 8-10 cycles. mean particle size surface charge were 208.7±7.8 nm -23.6±2.3 mv respectively. entrapment efficiency 66.4%. Drug stable during storage time 6±2°C 9 month, zeta-potential did not change significantly. concentration 5 mg/mL, there no degradation long term storage. Animal tests (rat paw lick test rabbit ear vein irritation test) used evaluate compared with that aqueous solution. These results suggest LM system is a promising option replace solutions treatment.