Formulation of intravenous Carbamazepine emulsions by SolEmuls® technology
作者： A. Akkar , R.H. Müller
DOI: 10.1016/S0939-6411(03)00028-6
关键词:
摘要: Oil in water (O/W) emulsions for parenteral nutrition can be employed as intravenous (i.v.) carriers drugs that are poorly soluble and oil by localising the drug interfacial lecithin layer, e.g. Amphotericin B emulsions. By now, emulsion production required organic solvents. SolEmuls technology localises layer a solvent-free high-pressure homogenisation process. was applied to produce Carbamazepine at increasing concentrations from 0.5 10 mg/ml. Drug powder Lipofundin were mixed homogenised 1500 bar. Characterisation of short-term stability performed photon correlation spectroscopy (PCS) laser diffractometry. incorporation (absence non-dissolved crystals) investigated light microscopy centrifugation test. The physically stable complete dissolution is possible up 3 Up mg/ml hybrid dispersions droplets ultrafine nanocrystals obtained. Both, suitable i.v. injectables regarding size stability.
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