Null genotypes of glutathione S-transferase µ1 and glutathione S-transferase θ1 are associated with osteosarcoma risk: A meta-analysis

摘要: Glutathione S-transferase (GST) genetic polymorphisms has been reported to be associated with osteosarcoma; however, the results of previous studies are conflicting. Thus, in present study, a meta-analysis was conducted investigate effects GSTM1 and GSTT1 on osteosarcoma risk. A literature search performed PubMed, Cochrane Library China National Knowledge Infrastructure databases identify case-control published prior March 2014. Data were extracted pooled odds ratios (OR) 95% confidence intervals (CI) calculated. In addition, Begg’s test used measure publication bias. Sensitivity analysis ensure accuracy results. The demonstrated no significant association between null genotype risk (OR=0.83; CI, 0.37–1.85). By contrast, revealed for comparison vs. non-null genotypes (OR=1.54; 1.09–2.19). conclusion, may an increased developing osteosarcoma. Further larger sample sizes well-designed methodologies required verify these conclusions.