Nucleophilic Substitution by Grignard Reagents on Sulfur Mustards
作者： Antonella Converso , Pierre-Loïc Saaidi , K. Barry Sharpless , M. G. Finn
DOI: 10.1021/JO0489869
关键词: Leaving group 、 Nucleophilic substitution 、 Sulfur mustard 、 Reactivity (chemistry) 、 Nucleophile 、 Reagent 、 Chemistry 、 Nonane 、 Sulfur 、 Organic chemistry
摘要: With proper activation of the leaving group, sulfur mustards react with Grignard reagents neighboring group participation atom. 2,6-Dichloro-9-thiabicyclo[3.3.1]nonane is especially useful in this regard, providing clean reactivity organomagnesium nucleophiles on a topologically constrained scaffold.
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