Development of one-pot three component reaction for the synthesis of N′-aryl-N-cyanoformamidines, essential precursors of formamidine pesticides family
作者： Antonio De Nino , Loredana Maiuolo , Monica Nardi , Raffaele Pasceri , Antonio Procopio
DOI: 10.1016/J.ARABJC.2015.06.016
关键词: Aryl 、 Organic chemistry 、 Aniline 、 Chemistry 、 Triethyl orthoformate 、 Alcohol 、 Azeotrope 、 Toluene 、 Distillation 、 Pesticide
摘要: Abstract Efficient one-pot three component reaction of aniline derivatives with cyanoamide and triethyl orthoformate at reflux in toluene affords N′-aryl-N-cyanoformamidines high yields just by the distillation azeotrope toluene/ethyl alcohol. Labelled d9-Amitraz is prepared application this procedure synthesis formamidine pesticides family.
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