A Double-Blind Study of Citalopram Versus Placebo in the Treatment of Compulsive Sexual Behaviors in Gay and Bisexual Men

摘要: Objective: Compulsive sexual behavior (CSB) is a condition characterized by loss of control over and repeated negative consequences, including unsafe sex. Selective serotonin reuptake inhibitors have been found to reduce CSB symptomatology in open-label trials. The objective this study was conduct preliminary double-blind, placebo-controlled evaluation the efficacy, acceptability, tolerability citalopram treatment CSB. Method: Twenty-eight men who sex with met threshold for on basis existing validated measures participated 12-week, double-blind trial 20 60 mg/day evaluate its effects symptoms. primary efficacy measure Yale-Brown Obsessive Scale-Compulsive Sexual Behavior. conducted from June 2002 April 2004. Results: Significant were obtained desire/drive (p <.05) frequency masturbation <.01) pornography use <.05). Both groups reduced risk, but did not differ significantly. Conclusions: This provides partial support effectiveness reducing symptoms population. Larger-scale trials are recommended determine public health benefits treatment.