Hepatitis C virus genotypes and subtypes circulating in Mainland China

摘要: The hepatitis C virus (HCV) exhibits global genotypic diversity. HCV genotyping plays an important role in epidemiological studies and clinical management. Herein, we report the results of genotype subtype detection a large number samples, as performed by independent laboratory China. In total, four genotypes 18 subtypes were identified among 32 030 patients from 29 provinces municipalities Five dominant detected 98.84% samples: 1b (n=16 713, 52.18%), 2a (n=9188, 28.69%), 3b (n=2261, 7.06%), 6a (n=2052, 6.41%) 3a (n=1479, 4.62%). Twelve rare detected, which (that is, 6b, 6j, 6q 6r) are reported for first time Chinese population. Genotypes 4, 5 7 not detected. Mixed infections found small portion samples (n=65, 0.203%), following combinations: 1b-2a, 1b-3b, 1b-6a, 3a-3b, 1b-3a 2a-6a. No mixed with found. Males, compared females, showed higher diversity, lower percentage HCV1b infections. Our analyses revealed comprehensive distribution patterns general population mainland differentially distributed on basis geography, sex age.