Influence of vitamin C on cadmium absorption and distribution in rats.
作者： Andrzej Grosicki
DOI: 10.1016/J.JTEMB.2004.06.003
关键词: Vitamin C 、 Cadmium chloride 、 Animal science 、 Aqueous solution 、 Tap water 、 Absorption (skin) 、 Cadmium 、 Chromatography 、 Distribution (pharmacology) 、 Ascorbic acid 、 Chemistry
摘要: The purpose of the present study was to evaluate effect a dietary vitamin C supplement on cadmium absorption and distribution in an animal model. An aqueous solution chloride (labelled with cadmium-109) given by gavage male Wistar rats for 28 days at daily dose corresponding 10 mg Cd/kg diet (1.0-1.2 b.w.). animals assigned groups 1 2 (45 per group) received standard laboratory LSM, tap water or supplemented ascorbic acid (1.5 mg/l), respectively. radioactivity samples measured using liquid scintillation counter (tissue samples) gas-flow automatic (ashed carcasses). fractional uptake cadmium-109 carcass organs evaluated within 32 after treatment dividing activity whole sample total administered days. Results were compared AUC (areas under concentration time curve) values. decreased burden content liver, kidneys, testicles muscles; highest decreases found testicles, lowest ones muscles. In addition, revealed improved body weight gain during experimental period.
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J. Kubová, J. Tulinská, E. Štolcová, A. Mošat'ová, E. Ginter, The influence of ascorbic acid on selected parameters of cell immunity in guinea pigs exposed to cadmium Zeitschrift für Ernährungswissenschaft. ,vol. 32, pp. 113- 120 ,(1993) , 10.1007/BF01614754
J. F. Dimanche, P. Kageruka, J. M. L. Kazadi, Efficacy of ronidazole (Ridzol-S MSD) in the prevention and treatment of Trypanosoma (Trypanozoon) brucei evansi infection in rats. Revue De Medecine Veterinaire. ,vol. 145, pp. 291- 296 ,(1990)
M. R. Spivey Fox, Bert E. Fry, Barbara F. Harland, M. E. Schertel, Cora E. Weeks, Effect of Ascorbic Acid on Cadmium Toxicity in the Young Coturnix The Journal of Nutrition. ,vol. 101, pp. 1295- 1305 ,(1971) , 10.1093/JN/101.10.1295
M. R. S. Fox, B. E. Fry, Cadmium Toxicity Decreased by Dietary Ascorbic Acid Supplements Science. ,vol. 169, pp. 989- 991 ,(1970) , 10.1126/SCIENCE.169.3949.989
Dorothea Appenroth, Klaus Winnefeld, Vitamin E and C in the prevention of metal nephrotoxicity in developing rats. Experimental and Toxicologic Pathology. ,vol. 50, pp. 391- 396 ,(1998) , 10.1016/S0940-2993(98)80024-9
M A Peraza, F Ayala-Fierro, D S Barber, E Casarez, L T Rael, Effects of micronutrients on metal toxicity. Environmental Health Perspectives. ,vol. 106, pp. 203- 216 ,(1998) , 10.1289/EHP.98106S1203
I. Guillot, B. Lohr, H. Weiser, S. Halbach, W. A. Rambeck, Influence of vitamin C on cadmium and mercury accumulation Journal of Animal Physiology and Animal Nutrition. ,vol. 80, pp. 167- 169 ,(1998) , 10.1111/J.1439-0396.1998.TB00521.X
H.R Griffiths, J Lunec, Ascorbic acid in the 21st century – more than a simple antioxidant Environmental Toxicology and Pharmacology. ,vol. 10, pp. 173- 182 ,(2001) , 10.1016/S1382-6689(01)00081-3
M. R. Spivey Fox, Richard M. Jacobs, A. O. Lee Jones, B. E. Fry, Charles L. Stone, Effects of Vitamin C and Iron on Cadmium Metabolism Annals of the New York Academy of Sciences. ,vol. 355, pp. 249- 261 ,(1980) , 10.1111/J.1749-6632.1980.TB21343.X
Sue Blackstone, R.J. Hurley, R.E. Hughes, Some inter-relationships between vitamin C (l-ascorbic acid) and mercury in the guinea-pig Food and Cosmetics Toxicology. ,vol. 12, pp. 511- 516 ,(1974) , 10.1016/0015-6264(74)90065-0