Membrane traffic en route to cancer
作者： S. M. Ferguson
关键词: Membrane 、 Cell biology 、 Cell growth 、 Phosphatidylinositol 3-Kinases 、 Cell surface receptor 、 Transduction (genetics) 、 Cancer 、 Intracellular 、 Oncogene Proteins 、 Biology
摘要: Binding of growth factors to cell surface receptors initiates complex intracellular signaling cascades that promote growth, survival, and proliferation ( 1 ). The membrane composition spatial arrangement organelles represents a critical network influences the transduction such signals. This close relationship blurs boundaries classifying proteins into simple categories as trafficking. challenge maintaining strict distinctions is illustrated on page 211 this issue by Wheeler et al. 2 ), who identify oncogenic functions for Rab35, protein involved in regulating endosomal traffic 3
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harvard.edu参考文章(13)
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