Beyond indigestion: emerging roles for lysosome-based signaling in human disease.

摘要: Lysosomes are becoming increasingly recognized as a hub that integrates diverse signals in order to control multiple aspects of cell physiology. This is illustrated by the discovery growing number lysosome-localized proteins respond changes growth factor and nutrient availability regulate mTORC1 signaling well identification MiT/TFE transcription factors (MITF, TFEB TFE3) shuttle between lysosomes nucleus elicit transcriptional response ongoing lysosome status. These findings have been paralleled advances human genetics connect mutations genes involved lysosomal broad range illnesses ranging from cancer neurological disease. review summarizes these new discoveries at interface biology