Regulation of adiposity and obesity risk by dietary calcium: Mechanisms and implications

摘要: Dietary calcium plays a pivotal role in the regulation of energy metabolism; high diets attenuate adipocyte lipid accretion and weight gain during periods overconsumption an energy-dense diet increase lipolysis preserve thermogenesis caloric restriction, thereby markedly accelerating loss. Intracellular Ca2+ has key regulating metabolism triglyceride storage, with increased intracellular resulting stimulation lipogenic gene expression lipogenesis, suppression lipolysis, filling adiposity. Moreover, we have recently demonstrated that calcitriol released response to low stimulates influx human adipocytes promotes Accordingly, suppressing levels by increasing dietary is attractive target for prevention management obesity. In support this concept, transgenic mice expressing agouti specifically a...