The role of glycosyl–phosphatidylinositol in signal transduction
作者： David R. Jones , Isabel Varela-Nieto
DOI: 10.1016/S1357-2725(97)00144-1
关键词: Biological activity 、 Biochemistry 、 Extracellular 、 Growth factor 、 Cell 、 Oligosaccharide 、 Signal transduction 、 Inositol 、 Biology 、 Phospholipase
摘要: Abstract Glycosyl–phosphatidylinositol (GPI) lipids have a structural role as protein anchors to the cell surface. In addition, they are implicated in hormone, growth factor and cytokine signal transduction. Their phosphodiesteric hydrolysis mediated by an activated phospholipase results generation of water soluble oligosaccharide species termed inositol phosphoglycan (IPG). This product has been demonstrated possess biological properties when added exogenously cells mimicking effects variety extracellular ligands. may be accomplished since IPG is generic for family closely related which released tissue-specific manner additionally cell-specific targets. Micro-organic synthesis recently able shed new light on this topic introduction defined analogues assessment their activity. These complemented findings observed with purified from sources thus strengthening belief that GPI/IPG signalling system represents truly novel aspect transmembrane signalling.
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